The Inflammatory Bowel Diseases (IBD) represent several
diseases in which there is inflammation of various segments of the intestinal
tract. In addition, there are many manifestations involving other systems of
the body, i.e., extra intestinal manifestations. IBD is felt to be a disease of
immune dysregulation. There has been great progress in elucidating the
epidemiology, genetics, and pathophysiology of IBD during the past severaldecades. Yet the overall incidence of IBD has continued to increase.
IBD has
also become a more global as well. There has also been a concomitant increase
in cases of IBD presenting in the pediatric age group. Numerous epidemiologic
studies have searched for factors that may shed light on the etiology of IBD.
However, the specific etiology(ies) of IBD remain elusive. Familial occurrence
of IBD is a well-established risk factor. A patient with IBD has a
significantly greater chance of having a first-degree relative who also has IBD. Read more...........
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